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Volume 13 Number 2

October 2004

In this issue

Peer-reviewed research, commentary and history from across military and veterans’ health.

BIOLOGICAL AGENTS And Anthrax

ANOTHER INTERESTING FORTNIGHT has come to an end, as our ADF ships and personnel pre-deploy to the Gulf. One of the key issues over this period has been the Australian…

BIOLOGICAL AGENTS Anthrax – Clinical characteristics and use as a biological warfare agent

AETIOLOGY ANTHRAX IS CAUSED BY the microorganism Bacillus anthracis, a large Gram positive rod-shaped bacterium which is commonly found singly or in pairs. The organism is capsulated in clinical specimens,…

RADIOLOGICAL AGENTS Beyond Chernobyl: A Short Report on Other Russian Nuclear Accidents1

THE EXPLOSION AT CHERNOBYL IN 1986 is the best known of the Russia n nuclear accidents. Recently, however, information has become available on other Russian nuclear accidents occurring in the…

CHEMICAL AGENTS CS and Reactive Airways Dysfunction

CS IS THE GENERIC NAME FOR the lacrimating agent 0-chlorobenzylidene malononitrile (2-chloroben zalmalonitrile), which was originally developed in 1928 by B.B. Corson and R.W. Stoughton1,2 CS is normally solid, which…

Editorial – A Special Edition

OVER THE LAST 12 YEARS, Australian Military Medicine has published a myriad of articles on all aspects of military medicine. One aspect that has been close to my heart, particularly…

BIOLOGICAL AGENTS Variola Virus – Destruction Imminenti

MOST MEDICAL PERSONNEL will not have seen smallpox, the disease resulting from infection by the variola virus. Hopefully, they never will. The last case of naturally acquired smallpox occurred in…

BOOK REVIEWS A Higher Form of Killing

"IN NO FUTURE WAR will the military be able to ignore poison gas. It is a higher form of killing". Thus, spoke Professor Fritz Harber, pioneer of gas warfare, on…

BIOLOGICAL AGENTS Alpha viruses

AETIOLOGY Alphaviruses are single-stranded RNA viruses, spherical in shape, and with a diameter of around 60-70nm. They have a lipoprotein envelope and have glycoprotein surface spikes containing major antigens. They…

Bioterrorism and Australia – Where to from here?

BIOTERRORISM, the deliberate use of biological weapons by a terrorist group, has become a major concern for Australia n medical, government and military agencies over the past two to three…

BOOK REVIEWS Britain and Biological Warfare: Expert advice and science policy – 1930-65

WHAT CAN YOU SAY to those who say that you can "cook up" biological warfare agents in the kitchen and kill thousands? Try positioning this account of the nascent British…

BIOLOGICAL AGENTS Brucellosis

AETIOLOGY BRU CELLOSIS IS CAUSED BY organisms of the genus Brucella; particularly B. melitensis, B. suis and B. abortus. These organisms are small Gram-negative, aerobic, coccobacilli and are facultative intracellular…

CHEMICAL AGENTS Contact Poisons: A Brief Touch

GAIL BELL, IN HER BOOK “THE POISON PRINCIPLE”, tries to establish why people use poison2. She looks back over the centuries, from Cleopatra and Socrates to more modern poisoners like…

CHEMICAL AGENTS Enhancing Resistance to Sulphur Mustard Injury: Expression of Glutathione S-Transferase in Human Keratinocytes – Developing a Model to Explore Pre-Exposure Strategies

THIS PAPER DESCRIBES the rationale for current work undertaken at the Chemical, Biological, Radiological and Nuclear Defence Centre (CBRN DC) investigating the feasibility of pre-exposure approaches to counteracting the toxicity…

Further Development of the Health Response to Chemical Biological and Radiological Emergencies: “A Multi-multi-Agency Response”

FROM 1998 TO 2000, the need for a civilian health response to chemical, biological and radiological (CBR) emergencies was identified and developed in preparation for the Sydney 2000 Olympic Games…

BIOLOGICAL AGENTS Genetic Vaccination: Can Plasmid DNA deliver its expectations?

VACCINES ARE EFFECTIVE AT protecting not only individuals but also communities. In the last fifty years, global immunisation programs have developed such strong "herd immunity" that some diseases, e.g. smallpox…

Medical NBC Training – Where to now?

Nuclear, Biological and Chemical (NBC) Warfare remains as much a risk today as it has been in the past. With increased numbers of proliferating nations, increased industrialization and poorly effective…

BIOLOGICAL AGENTS Melioidosis: Pathogenesis, Epidemiology, Treatment and Detection

MELIOIDOSIS, AN INFECTION CAUSED BY the bacillus Burkholderia pseudomallei, is endemic tropical and subtropical areas. In humans, the disease is caused by ingestion or by contact with contaminated water through…

CHEMICAL AGENTS Phosgene – A Research Review

Phosgene is a toxic substance which causes fatal permeability-type (non-cardiogenic) pulmonary oedema on inhalation. Phosgene is a simple low-molecular-weight synthetic chemical which was used as a chemical warfare agent in…

CHEMICAL AGENTS Phosgene – Chemical Weapon and Industrial Chemical

PHOSGENE IS USED IN industry widely and has potential use as a chemical weapon. In this paper, its chemistry, uses and effects will be reviewed. CHEMISTRY Phosgene (COCl2) was first…

BIOLOGICAL AGENTS Plague – A Review

AETIOLOGY PLAGUE IS CAUSED BY the bacterium Yersinia pestis, a small Gram-negative, non-motile coccobacillus, which has a characteristics bipolar “safety-pin” appearance when stained. Although this organism is non-sporing, it may…

BOOK REVIEWS Plague Wars: A true story of biological warfare

"BIOLOGICAL WARFARE HAS ALREADY BEGUN. In the former Soviet Union, the military has perfected small­pox, anthrax and plague as biological warheads on intercontinental missiles can reach London, New York and…

BIOLOGICAL AGENTS Q Fever

AETIOLOGY Q Fever is caused by the rickettsial pathogen Coxiella burnetii, a minute bacterium-like organism which may vary in size and shape. The smaller organisms will pass through microbial filters…

BIOLOGICAL AGENTSRicin – A research review

Ricin is a toxin of plant origin which causes fatal permeability-type (non-cardiogenic) pulmonary oedema on inhalation of the aerosol. Ricin is composed of two chains, linked by a disulfide bond.…

BIOLOGICAL AGENTS Rocky Mountain Spotted Fever

AETIOLOGY ROCKY MOUNTAIN SPOTTED FEVER (RMSF) is caused by the rickettsial pathogen Rickettsia rickettsii, an obligate, intracellular parasite. These microorganisms are very small (0.3m-0.5m). Extracellular R. rickettsii ceases metabolic activity…

BOOK REVIEWS The Hot Zone

EBOLA AND MARBURG ARE HIGHLY LETHAL viral haemorrhagic fevers usually only seen in the wilds of Africa. In The Hot Zone, Richard Preston has detailed the recent outbreak of Ebola…

BOOK REVIEWS The Limits of Safety: Organisations, Accidents and Nuclear Weapons

MANY MAY WONDER why a book on US military nuclear weapon safety has relevance to a health journal. The book's first, chapter sets the scene with a generic discussion of…

BIOLOGICAL AGENTS The Plague – Its Revelance to Travel Medicine

THE PLAGUE, RECOGNISED BY MOST FROM its description as the Black Death, is alive and well today. It is an enzootic disease of peridomestic and wild rodents caused by the…

BIOLOGICAL AGENTS Tularaemia

TULARAEMIAS CAUSED BY the intracellular pathogen Francisella tularensis, a small, pleomorphic, aerobic, Gram-negative coccobacillus which requires a complex cysteine-containing growth medium for laboratory cultures. Capsules may form in tissues. The…

RESPONSE White Powder Incidents: Did we manage and could we manage again?

The use of biological weapons has been around since before the siege of Kaffa in 1346 when the Tartars catapulted plague-infected bodies over the ramparts. The potential for terrorists to…