Abstract The standard treatment of nerve agent poisoning is pretreatment with the carbamate pyridostigmine, and post-exposure therapy with atropine, an oxime (PAM, toxogonin or HI-6) and diazepam. Some of the literature published in 1998 bearing on this treatment procedure, and improvements to it, is reviewed in this document. A detailed study of the pharmacokinetics of… Read more »
ABSTRACT Ricin is a toxin of plant origin which causes fatal permeability-type (non-cardiogenic) pulmonary oedema on inhalation of the aerosol. Ricin is composed of two chains, linked by a disulfide bond. The B-chain acts to bind the toxin to cell membranes and assist in internalization of the A-chain, which inhibits protein synthesis by enzymatic action… Read more »
ABSTRACT Phosgene is a toxic substance which causes fatal permeability-type (non-cardiogenic) pulmonary oedema on inhalation. Phosgene is a simple low-molecular-weight synthetic chemical which was used as a chemical warfare agent in World War I. Phosgene attacks the epithelial lining of the respiratory tract. This paper summarises the current state of knowledge about the actions of… Read more »
