Army Malaria Institute – its Evolution and Achievements. Fourth Decade (1st Half): 1995-2000

By Karl H Rieckmann , Qin Cheng , Robert D Cooper , Michael D Edstein , Stephen P Frances , Ivor Harris , Scott Kitchener , Barbara Kotecka and Peter Nasveld In   Issue Volume 22 No. 1 .

Abstract

During the 1995-2000 quinquennium, the Army Malaria Research Unit (AMRU) was re-named the Australian Army Malaria Institute (AMI) and re-located from Sydney to a modern purpose-built facility in Brisbane. Its international recognition as a centre of excellence for malaria research was further enhanced by the establishment of a molecular parasitology laboratory to investigate drug resistance. During this period AMI deployed outbreak management teams in response to the hundreds of soldiers who suffered from malaria in Bougainville and Timor Leste due to inadequate personal protection and chemoprophylactic measures. Between 10-20% of affected soldiers experienced their first attack of falciparum or vivax malaria overseas for failing to comply with doxycycline prophylaxis or, possibly, for taking doxycycline which had been degraded by exposure to adverse environmental conditions. By contrast, 80-90% of primary episodes of malaria did not occur until after return to Australia, simply because the 14-day post-exposure primaquine course was either ineffective in eradicating residual liver stages of Plasmodium vivax or had not been taken as prescribed. Field studies with tafenoquine, a slowly-eliminated analogue of primaquine, indicated that this drug might eventually replace primaquine and even prevent malaria while overseas. In a further field study, atovaquone/proguanil (Malarone®) proved to be just as effective as doxycycline, suggesting that it could be used as an alternative drug for malaria prophylaxis. Laboratory-based studies with Mannich base,  artemisinin, and third-generation antifolate compounds provided further evidence of their potential value for the control of drug-resistant falciparum malaria.

Progress was also made in evaluating drug resistance and diagnostic procedures and in identifying molecular markers of parasite resistance to antimalarial drugs, such as atovaquone. Two novel insect repellents and a self-erecting low-profile bednet provided good protection against mosquito bites. Surveys on the distribution and speciation of anopheline mosquitoes in Papua New Guinea were extended to another five provinces and, whilst DNA analysis was still in progress, early findings indicated a marked diversity of genotypes in anopheline species. Towards the end of the quinquennium, AMI became involved in efforts to provide Australian Defence Force personnel with better protection against other mosquito- borne diseases, such as Ross River virus, dengue and Japanese encephalitis.

 

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Acknowledgements

References

References

1. Rieckmann KH. The chequered history of malaria control: are new and better tools the ultimate answer? Ann Trop Med Parasitol 2006; 100(8): 647-662.

2. Rieckmann KH, Sweeney AW. Army Malaria Institute: its evolution and achievements. First decade: 1965- 1975. JMVH 2012; 20 (2): 17-24.

3. Rieckmann KH, Edstein MD, Cooper RD, Sweeney AW. Army Malaria Institute: its evolution and achievements. Second decade: 1975-1985. JMVH 2012; 20 (3): 9-20.

4. Rieckmann KH, Sweeney AW, Edstein MD, Cooper RD, Frances SP. Army Malaria Institute: its evolution and achievements. Third decade (1st half): 1985-1990. JMVH 2012; 20 (4): 59-70.

5. Rieckmann KH, Frances SP, Kotecka BM, Cooper RD, Shanks GD, Sweeney AW, Edstein MD. Army Malaria Institute – its evolution and achievements. Third decade (2nd half): 1990-1995. JMVH 2013; 21 (2): 36-56.

6. The Director-General’s Task Force on Malaria Prevention and Control. Reports of the first and second meetings. 21-24 October 1996, Geneva, Switzerland and 22-24 October 1997, Cairo, Egypt. Division of Control of Tropical Diseases. World Health Organization, Geneva. WHO/CTD/TF/98.1.

7. Army Malaria Institute. Report on Scientific Activities. 1996-1997.

8. Elmes NJ, Bennett SM, Nasveld PE. Malaria in the Australian Defence Force: the Bougainville experience.

ADF Health 2004; 5: 69-72.

9. Kitchener S. Malaria in the Australian Defence Force associated with the InterFET peacekeeping operation in East Timor. Mil Med 2002; 167: 3-4.

10. Kitchener SJ, Auliff AM, Rieckmann KH. Malaria in the Australian Defence Force during and after participation in the International Force in East Timor (INTERFET). Med J Aust 2000; 173: 583-585.

11. Kitchener S. Epidemiology of malaria from East Timor among Australian Defence personnel. Trans R Soc Trop Med Hyg 2002; 96: 376-377.

12. Rieckmann KH, Sax LJ, Campbell GH, Mrema JE. Drug sensitivity of Plasmodium falciparum. An in-vitro microtechnique. Lancet 1978; 1: 22-

13. Desjardins RE, Canfield CJ, Haynes JD, Chulay JD. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Ag Chemother 1979; 16: 710-718.

14. Batty KT, Davis TME, Thu LT, Binh TQ, Anh TK, Ilett KF. Selective high-performance liquid chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria. J Chromatogr Biomed Sci Appl 1966; 677: 345-350.

15. Kotecka BM, Rieckmann KH, Davis ME, Batty KT, Ilett KF. Comparison of bioassay and high performance liquid chromatography assay of artesunate and dihydroartemisinin in plasma. Acta Tropica 2003; 87: 371-375.

16. Chen N, Russell B, Staley J, Kotecka B, Nasveld P, Cheng Q. Sequence polymorphisms in prfct are strongly associated with chloroquine resistance in Plasmodium falciparum. J Infect Dis 2001; 183 (10): 1543-1545.

17. Chen N, Russell B, Fowler E, Peters J, Cheng Q. Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than Pfcrt and Pfmdr1. J Infect Dis 2002; 185: 405-406.

18. Chen N, Baker J, Ezard N, Burns M, Edstein M, Cheng Q. Molecular evaluation of the efficacy of chloroquine

treatment of uncomplicated Plasmodium falciparum in East Timor. Am J Trop Med Hyg 2002; 67: 64-66.

19. Ezard N, Burns M, Lynch C, Cheng Q, Edstein M. Efficacy of chloroquine in the treatment of uncomplicated Plasmodium falciparum infection in East Timor, 2000. Acta Tropica 2003; 88: 87-90.

20. Korsinczky M, Chen N, Kotecka B, Saul A, Rieckmann K, Cheng Q. Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site. Antimcrob Ag Chemother 2000; 44: 2100-2108.

21. Van Vugt M, Edstein MD, Proux S, Lay K, Ooh M, Looareesuwam S, White NJ, Nosten F. Absence of interaction between artesunate and atovaquone-proguanil. Eur J Clin Pharmacol 1999; 55: 469-474.

22. Nasveld P, Edstein M, Kitchener S, Rieckmann K. Comparison of the effectiveness of atovaquone/proguanil combination and doxycycline in the chemoprophylaxis of malaria in Australian Defence Force personnel. Am J Trop Med Hyg Suppl 2000; abstract no.1391.

23. Baird JK, Rieckmann KH. Can primaquine therapy for vivax malaria be improved? Trends Parasitol 2003; 19: 115-120.

24. Rieckmann KH, Yeo A, Davis D, Hutton DC, Wheatley PF, Simpson R. Recent military experience with malaria chemoprophylaxis. Med J Aust 1993; 158: 446-449.

25. Kitchener S, Nasveld P. Bennett S, Torresi J. Adequate Primaquine for Vivax Malaria. J Trav Med 2005; 12: 133-135.

26. Edstein MD, Kocisko DA, Brewer TG, Walsh DS, Eamsila C, Charles BG. Population pharmacokinetics of the new antimalarial agent tafenoquine in Thai soldiers. Br J Clin Pharmacol 2001; 52: 663-670.

27. Rieckmann KH. The future of Etaquine. In: Symposium on Etaquine, held in association with the 46th Annual Meeting of the American Society of Tropical Medicine and Hygiene 1997 December 7-11; Florida, USA.

28. Walsh DS, Eamsila C, Sasiprapha T, Sangkharomya S, Khaewsathien P, Supakalin P, Tang P, Jarasrumgsichol P, Cherdchu C, Edstein MD, Rieckmann KH, Brewer TG. Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant Plasmodium falciparum malaria. J Inf Dis 2004; 190: 1456-1463.

29. Walsh DS, Eamsila C, Sasiprapha T, Sangkharomya S, Khaewsathien P, Supakalin P, Tang P, Jarasrumgsichol P, Cherdchu C, Edstein MD, Rieckmann KH, Brewer TG. Prevention of Plasmodium vivax and multiple-drug resistant P falciparum malaria with monthly tafenoquine in Thailand. Contagion 2005; 2: 58-62.

30. Edstein MD, Walsh DS, Eamsila C, Sasiprapha T, Nasveld PE, Kitchener S, Rieckmann KH. Malaria

prophylaxis/radical cure: Recent experiences of the Australian Defence Force. Med Trop 2001; 61: 56-58. History Journal of Military and Veterans’ Health

31. Kocisko DA, Walsh DS, Eamsila C, Edstein MD. Measurement of tafenoquine (WR238605) in humanplasma, and venous and capillary blood by High-Pressure Liquid Chromatography. The Drug Monitor 2000; 22: 184-189.

32. Edstein MD, Kocisko DA, Walsh DS, Eamsila C, Charles BG, Rieckmann KH. Plasma concentrations of tafenoquine, a new long-acting antimalarial agent, in Thai soldiers receiving monthly prophylaxis. Clin Infect Dis 2003; 37: 1654-1658.

33. Nasveld P, Kitchener S, Edstein M, Rieckmann KH. Comparison of tafenoquine (WR238605) and primaquine in the post-exposure (terminal) prophylaxis of vivax malaria in Australian Defence Force personnel. Trans R Soc Trop Med Hyg 2002; 96: 683-684.

34. Elmes NJ, Nasveld PE, Kitchener SJ, Kocisko DA, Edstein MD. Comparison of three different dose regimens of tafenoquine versus primaquine for post exposure prophylaxis of vivax malaria in the South West Pacific. Trans Roy Soc Trop Med Hyg 2008; 102: 1095-1101.

35. Jensen NP, Ager AL, Bliss RA, Canfield CJ, Kotecka B, Rieckmann KH, Terpinski J, Jacobus DP. Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials. J Med Chem 2001; 44: 3925-3931.

36. Kotecka BM, Barlin GB, Edstein MD, Rieckmann KH. New quinoline di- Mannich bases with greater antimalarial activity than chloroquine, amodiaquine or pyronaridine. Antimicrob Ag Chemother 1997; 41: 1369-1374.

37. Haynes RK, Fugmann B, Stetter J, Rieckmann K, Heilmann H-D, Chan H-W, Cheung M-K, Lam W-L, Wong H-N, Croft SL, Vivas L, Rattray L, Stewart L, Peters W, Robisnson BL, Edstein MD, Kotecka B, Kyle DE, Beckermann B, Gerisch M, Radtke M, Schmuck G, Steinke W, Wollborn U, Schmeer K, Roemer A. Artemisone – a highly active antimalarial drug of the artemisinin class. Angew Chem Int Ed 2006; 45: 2082-2088.

38. Frances SP, Cooper RD, Sweeney AW. Laboratory and field evaluation of the repellents, deet, CIC-4 and AI3-37220, against Anopheles farauti (Diptera: Culicidae) in Australia. J Med Ent 1998; 35: 690-693.

39. Frances SP, Cooper RD, Popat S, Sweeney AW. Field evaluation of the repellents, deet, CIC-4 and AI3- 37220, against Anopheles (Diptera: Culicidae) in Lae, Papua New Guinea. J Am Mosq Control Assoc 1999; 14: 339-341.

40. Frances SP, Cooper RD, Popat S, Beebe NW. Field evaluation of repellents containing deet and AI3-37220, against Anopheles koliensis (Diptera: Culicidae) in Papua New Guinea. J Am Mosq Control Assoc 2001; 17: 42-44.

41. Frances SP, Cooper RD, Beebe NW. Evaluation of personal protection measures against mosquitoes in Papua New Guinea. Arbovirus Res Aus 2001; 8: 155-159.

42. Hii J, Frances SP, Canyon D. Personal protective measures against disease vectors. In: Leggat PA (ed) Primer of Travel Medicine, Second Edition, ACTM Publications,1998: 173-182.

43. Frances SP, Cooper RD, Gupta RK, Debboun M. Efficacy of a new self supporting low profile bednet for personal protection against Anopheles farauti (Diptera: Culicidae) in a village in Papua New Guinea. J Med Entomol 2003; 40: 68-72.

44. Cooper RD, Waterson DGE, Frances SP, Beebe NW, Sweeney AW. Speciation and distribution of the members of the Anopheles punctulatus (Diptera: Culicidae) group in Papua New Guinea. J Med Entomol 2002; 39: 16-27.

45. Cooper RD, Waterson DGE, Frances SP, Beebe NW, Sweeney AW. The Anopheline Fauna of Papua New Guinea. J Am Mosq Control Assoc 2006; 22: 213-221.

46. Cooper RD, Waterson DGE, Bangs MJ, Beebe NW. Rediscovery of Anopheles (Cellia) clowi (Diptera: Culicidae), a rarely recorded member of the Anopheles punctulatus Group. J Med Entomol 2000; 37: 840- 845.

47. Beebe NW, Cooper RD. Systematics of malaria vectors with particular reference to the Anopheles punctulatus group. (invited review) Int J Parasitol 2000; 30:1-17.

48. Cooper RD, Waterson DGE, Frances SP, Beebe NW, Pluess B, Sweeney AW. Malaria vectors in Papua New Guinea. 2009 Int J Parasitol 39: 1495-1501.

49. Cooper RD, Frances SP. 2002. Malaria vectors on Buka and Bougainville Islands, Papua New Guinea. J Am Mosq Control Assoc 2002; 18: 100-106.

50. Beebe NW, Bakote’e B, Ellis JT, Cooper RD. Differential ecology of Anopheles punctulatus and three members of the Anopheles farauti complex of mosquitoes on Guadalcanal, Solomon Islands, identified by PCR-RFLP analysis. Med Vet Entomol 2000; 14: 308-312.

51. Beebe NW, Ellis JT, Cooper RD, Saul A. DNA sequence analysis of the ribosomal DNA ITS2 region for the Anopheles punctulatus group of mosquitoes. Insect Mol Biol 1999; 8: 381-390.

52. Beebe NW, Cooper, RD, Morrison DA, Ellis JT. Subset partitioning of the ribosomal DNA small subunit and its effects on the phylogeny of the Anopheles punctulatus group. Insect Mol Biol 2000; 9: 515-520.

53. Beebe NW, Cooper RD. Distribution and evolution of the Anopheles punctulatus group (Diptera: Culicidae) in Australia and Papua New Guinea. (invited review) Int J Parasitol 2002; 32: 563-574.

54. Beebe NW, Cooper RD, Morrison DA, Ellis JT. A phylogenetic study of the Anopheles punctulatus group of malaria vectors comparing rDNA sequence alignments of the mitochondrial and nuclear small ribosomal subunits. Mol Phylogenet Evol 2001; 17: 430-436.

55. Bower JE, Dowton M, Cooper RD, Beebe NW. Intraspecific Concerted Evolution of the rDNA ITS1 in Anopheles farauti sensu stricto (Diptera: Culicidae) reveals recent patterns of population structure. J Mol Evol 2008; 67: 397-477.

56. Beebe NW, Cooper RD, Foley DH, Ellis JT. Populations of the southwest Pacific malaria vector Anopheles farauti s.s. revealed by ribosomal DNA transcribed spacer polymorphisms. Heredity 2000; 84: 244-253.

57. Beebe NW, Maung J, van den Hurk AF, Ellis JT, Cooper RD. Ribosomal DNA spacer genotypes of the Anopheles bancroftii group (Diptera: Culicidae) from Australia and Papua New Guinea. Insect Mol Biol 2001; 10: 407-413.

58. Alquezar DE, Hemmerter S, Cooper RD, Beebe NW. Incomplete concerted evolution and reproductive isolation at the rDNA locus uncovers nine cryptic species within Anopheles longirostris from Papua New Guinea. BMC Evolutionary Biology 2010; 10: 392.

59. Frances SP, Cooper RD, Chen N, Cheng Q. Surveillance of potential arbovirus vectors at Shoal Water Bay military training area, Queensland. Arbovirus Res Aus 2001; 8: 160-163.

60. Frances SP, Cooper RD, Rowcliffe KL, Chen N, Cheng Q. Occurrence of Ross River virus and Barmah Forest Virus in mosquitoes at Shoalwater Bay Military Training Area, Queensland, Australia. J Med Entomol 2004; 41:115-120.

61. Clifford K, Frances S, Nasveld P, Russell B. Preventative health advice to deploying units. Aust Mil Med 1999; 8: 7-12.

62. Kitchener S, Reid M, Baade L, Taylor C. Serological testing, clinical incidence and serosurveillance of dengue in the Australian Defence Force, East Timor. Arbovirus Res Aust 2000; 8: 203-207.

63. Kitchener S. The development of dengue vaccines and their military significance. Aust Mil Med, 2000; 9(2): 71-73.

64. Kitchener S, Leggat P, Brennan L, McCall, B. The importation of Dengue by soldiers returning from East Timor to north Queensland. J Travel Med 2002; 9: 180-183.

65. Kitchener S, Brennan L, Hueston L, Nasveld P. Evaluation of the Japanese encephalitis vaccine by subcutaneous and intradermal routes of administration. Arbovirus Res. Aust. 2000; 8: 208-211.

66. Kitchener S, Nasveld P, Brennan L, Ward D. Comparative safety and efficacy of subcutaneous and intradermal administration of inactivated Japanese encephalitis vaccine during pre-deployment preparations in the Australian Defence Force. Mil Med 2006; 171(12): 1190-1195

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